TIME

Dec. 1 has been World AIDS Day since 1988 — but though the awareness and activism around the diseases has changed drastically during the years between then and now.

To see just how much our understanding and attitudes have evolved, take a look back at TIME’s coverage of AIDS through these seven essential stories:

Hunting for the Hidden Killers by Walter Isaacson, Jul. 4, 1983

This 1983 cover story wasn’t the first time AIDS appeared in the pages of TIME — in 1982, an article had explained the new “plague” to readers — but the tale of the “disease detectives” at the Centers for Disease Control and the National Institutes of Health highlights just how little was known about the disease:

Based on what is known so far, two theories have emerged. One is that AIDS is caused by a specific agent, most probably a virus. “The infectious-agent hypothesis is…

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